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Article

Saccharomyces cerevisiae genetics predicts candidate therapeutic genetic interactions at the mammalian replication fork.

G3 (Bethesda, Md.) - 1 Feb 2013

van Pel Derek M, Stirling Peter C, Minaker Sean W, Sipahimalani Payal, Hieter Philip

Abstract excerpt

The concept of synthetic lethality has gained popularity as a rational guide for predicting chemotherapeutic targets based on negative genetic interactions between tumor-specific somatic mutations and a second-site target gene. One hallmark of most cancers that can be exploited by chemotherapies is chromosome instability (CIN). Because chromosome replication, maintenance, and segregation represent conserved and...

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Identifiers

PMID: 23390603
DOI: 10.1534/g3.112.004754
PMCID: PMC3564987

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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