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Article

Synthetic lethal targeting of superoxide dismutase 1 selectively kills RAD54B-deficient colorectal cancer cells.

Genetics - 1 Nov 2013

Sajesh Babu V, Bailey Melanie, Lichtensztejn Zelda, Hieter Philip, McManus Kirk J

Abstract excerpt

Synthetic lethality is a rational approach to identify candidate drug targets for selective killing of cancer cells harboring somatic mutations that cause chromosome instability (CIN). To identify a set of the most highly connected synthetic lethal partner genes in yeast for subsequent testing in mammalian cells, we used the entire set of 692 yeast CIN genes to query the genome-wide synthetic lethal datasets....

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Source

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Identifiers

PMID: 24002644
DOI: 10.1534/genetics.113.156836
PMCID: PMC3813862

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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