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Article

Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing.

Proceedings of the National Academy of Sciences of the United States of America - 3 Mar 2009

McManus Kirk J, Barrett Irene J, Nouhi Yasaman, Hieter Philip

Abstract excerpt

Mutations that cause chromosome instability (CIN) in cancer cells produce "sublethal" deficiencies in an essential process (chromosome segregation) and, therefore, may represent a major untapped resource that could be exploited for therapeutic benefit in the treatment of cancer. If second-site unlinked genes can be identified, that when knocked down, cause a synthetic lethal (SL) phenotype in combination with a...

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Source

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Identifiers

PMID: 19218431
DOI: 10.1073/pnas.0813414106
PMCID: PMC2651317

Genes

FEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing.PMID 19218431Read ↗

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