Article
Synthetic lethal genetic interactions that decrease somatic cell proliferation in Caenorhabditis elegans identify the alternative RFC CTF18 as a candidate cancer drug target.
Molecular biology of the cell - 1 Dec 2009
McLellan Jessica, O'Neil Nigel, Tarailo Sanja, Stoepel Jan, Bryan Jennifer, Rose Ann, Hieter Philip
Abstract excerpt
Somatic mutations causing chromosome instability (CIN) in tumors can be exploited for selective killing of cancer cells by knockdown of second-site genes causing synthetic lethality. We tested and statistically validated synthetic lethal (SL) interactions between mutations in six Saccharomyces cerevisiae CIN genes orthologous to genes mutated in colon tumors and five additional CIN genes. To identify which SL...
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