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Article

An evolutionarily conserved synthetic lethal interaction network identifies FEN1 as a broad-spectrum target for anticancer therapeutic development.

PLoS genetics - 1 Jan 2013

van Pel Derek M, Barrett Irene J, Shimizu Yoko, Sajesh Babu V, Guppy Brent J, Pfeifer Tom, McManus Kirk J, Hieter Philip

Abstract excerpt

Harnessing genetic differences between cancerous and noncancerous cells offers a strategy for the development of new therapies. Extrapolating from yeast genetic interaction data, we used cultured human cells and siRNA to construct and evaluate a synthetic lethal interaction network comprised of chromosome instability (CIN) genes that are frequently mutated in colorectal cancer. A small number of genes in this...

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Identifiers

PMID: 23382697
DOI: 10.1371/journal.pgen.1003254
PMCID: PMC3561056

Genes

FEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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