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Article

AKT collaborates with ERG and Gata1s to dysregulate megakaryopoiesis and promote AMKL.

Leukemia - 1 Jun 2013

Stankiewicz M J, Crispino J D

Abstract excerpt

The requirement that leukemic Gata1 mutations be present in cells harboring trisomy 21 led to the discovery that overexpression of ERG drives aberrant megakaryopoiesis. Given that constitutive PI3K/AKT signaling is a frequent component of hematologic malignancies and the relationship between AKT and Notch in this lineage, we studied the crosstalk between AKT signaling and ERG in megakaryopoiesis. We discovered...

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Share to Cell Line, Tumor
Share to GATA1 Transcription Factor
Share to Hematopoiesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Megakaryoblastic, Acute

Share to Phosphorylation

Share to Proto-Oncogene Proteins c-akt

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Share to Transcriptional Regulator ERG

Source

Open in PubMed Open full text

Identifiers

PMID: 23380710
DOI: 10.1038/leu.2013.33
PMCID: PMC3915509

Genes

ERG
FOXO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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