Article
Targeted inhibition of cooperative mutation- and therapy-induced AKT activation in AML effectively enhances response to chemotherapy.
Leukemia - 1 Jul 2021
Estruch Montserrat, Reckzeh Kristian, Vittori Camilla, Centio Anders, Ali Mina, Engelhard Sophia, Zhao Ling, Won Kyoung Jae, Liu Paul, Porse Bo Torben, Theilgaard-Mönch Kim
Abstract excerpt
Most AML patients exhibit mutational activation of the PI3K/AKT signaling pathway, which promotes downstream effects including growth, survival, DNA repair, and resistance to chemotherapy. Herein we demonstrate that the inv(16)/KITD816Y AML mouse model exhibits constitutive activation of PI3K/AKT signaling, which was enhanced by chemotherapy-induced DNA damage through DNA-PK-dependent AKT phosphorylation....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.