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Article

The Proto-Oncogene ERG in Megakaryoblastic Leukemias

1 Sept 2005

Abstract excerpt

Aneuploidy is one of the hallmarks of cancer. Acquired additions of chromosome 21 are a common finding in leukemias, suggesting a contributory role to leukemogenesis. About 10% of patients with a germ line trisomy 21 (Down syndrome) are born with transient megakaryoblastic leukemia. We and others have shown acquired mutations in the X chromosome gene GATA1 in all these cases. The gene or genes on chromosome 21...

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PMID: 16140924
DOI: 10.1158/0008-5472.can-05-0147

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The Proto-Oncogene ERG in Megakaryoblastic LeukemiasPMID 16140924Read ↗

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