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Article

PEAR1 attenuates megakaryopoiesis via control of the PI3K/PTEN pathway

11 May 2013

Abstract excerpt

Platelet endothelial aggregation receptor-1 (PEAR1) participates in platelet aggregation via sustaining αIIbβ3 activation. To investigate the role of PEAR1 in platelet formation, we monitored and manipulated PEAR1 expression in vitro in differentiating human CD34(+) hematopoietic stem cells and in vivo in zebrafish embryos. PEAR1 expression rose during CD34(+) cell differentiation up to megakaryocyte (MK)...

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PMID: 23667054
DOI: 10.1182/blood-2012-10-462887

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