Activation of NOTCH signaling impedes cell proliferation and survival in acute megakaryoblastic leukemia.

doi:10.1016/j.exphem.2024.104255

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Article

Activation of NOTCH signaling impedes cell proliferation and survival in acute megakaryoblastic leukemia.

Experimental hematology - 1 Sept 2024

Ong Kelly Ooi Kee, Mok Michelle Meng Huang, Niibori-Nambu Akiko, Du Linsen, Yanagida Masatoshi, Wang Chelsia Qiuxia, Bahirvani Avinash Govind, Chin Desmond Wai Loon, Koh Cai Ping, Ng King Pan, Yamashita Namiko, Jacob Bindya, Yokomizo Tomomasa, Takizawa Hitoshi, Matsumura Takayoshi, Suda Toshio, Lau Jie-Ying Amelia, Tan Tuan Zea, Mori Seiichi, Yang Henry, Iwasaki Masayuki, Minami Takashi, Asou Norio, Sun Qiao-Yang, Ding Ling-Wen, Koeffler H Phillip, Tenen Daniel G, Shimizu Ritsuko, Yamamoto Masayuki, Ito Yoshiaki, Kham Shirley Kow Yin, Yeoh Allen Eng-Juh, Chng Wee Joo, Osato Motomi

Abstract excerpt

The genetic lesions that drive acute megakaryoblastic leukemia (AMKL) have not been fully elucidated. To search for genetic alterations in AMKL, we performed targeted deep sequencing in 34 AMKL patient samples and 8 AMKL cell lines and detected frequent genetic mutations in the NOTCH pathway in addition to previously reported alterations in GATA-1 and the JAK-STAT pathway. Pharmacological and genetic NOTCH...

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Identifiers

PMID: 38876252
DOI: 10.1016/j.exphem.2024.104255

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