Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

STAT1 promotes megakaryopoiesis downstream of GATA-1 in mice

3 Dec 2007

Abstract excerpt

Thrombocytosis is associated with inflammation, and certain inflammatory cytokines, including IFN-gamma, stimulate megakaryocyte and platelet production. However, the roles of IFN-gamma and its downstream effector STAT1 in megakaryocyte development are poorly understood. We previously reported that STAT1 expression was significantly downregulated in Gata1-knockdown murine megakaryocytes, which also have impaired...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Eosinophilic Disorders and Syndromes
Share to Myeloproliferative Neoplasms: Diagnosis and Treatment
Share to Platelet Disorders and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18060035
DOI: 10.1172/jci33010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

STAT1 promotes megakaryopoiesis downstream of GATA-1 in micePMID 18060035Read ↗

Loss of Stat1 decreases megakaryopoiesis and favors erythropoiesis in a JAK2-V617F-driven mouse model of MPNs.Semantic proximity Read ↗

GATA1 in Normal and Pathologic Megakaryopoiesis and Platelet Development.Semantic proximity Read ↗

A functional role of Stat3 in in vivo megakaryopoiesis.Semantic proximity Read ↗

Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cellsSemantic proximity Read ↗

Early block to erythromegakaryocytic development conferred by loss of transcription factor GATA-1.Semantic proximity Read ↗

RUNX-1 haploinsufficiency causes a marked deficiency of megakaryocyte-biased hematopoietic progenitor cellsSemantic proximity Read ↗

Deletion of Stat3 in hematopoietic cells enhances thrombocytosis and shortens survival in a JAK2-V617F mouse model of MPNSemantic proximity Read ↗

GATA1--a player in normal and leukemic megakaryopoiesis.Semantic proximity Read ↗

Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosisSemantic proximity Read ↗

Role of GATA-1 in proliferation and differentiation of definitive erythroid and megakaryocytic cells in vivo.Semantic proximity Read ↗

RUNX1 haploinsufficiency causes a marked deficiency of megakaryocyte-biased hematopoietic progenitor cells: Mechanistic studies and drug correctionSemantic proximity Read ↗

GATA1-defective immune-megakaryocytes as possible drivers of idiopathic pulmonary fibrosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.