Article

PITPβ Drives JAK2 V617F-Mediated Myeloproliferative Neoplasms by Promoting PtdIns(3,4)P <sub>₂</sub> -Dependent AKT Hyperactivation

2026-03-30

Abstract excerpt

<h4>ABSTRACT</h4> JAK2 is a key regulator of cytokine-mediated proliferative signaling in hematopoietic stem and progenitor cells. Activating mutations, most commonly JAK2 V617F, trigger aberrant cytokine signaling driving the pathogenesis of myeloproliferative neoplasms (MPNs). Phosphatidylinositol transfer proteins (PITPs) facilitate phosphoinositide synthesis by delivering phosphatidylinositol to lipid kinases...

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Literature Corpus work: 76a29625-5ac7-5a0a-ad28-0ae2ff578207
DOI: 10.64898/2026.03.26.714558

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