Back to search

Article

Prognostic impacts of the three AKT isoforms in acute myeloid leukemia. Is AKT3 the bad AKTOR?

2023-12-01

Abstract excerpt

The PI3K-AKT-mTOR pathway lies at the confluence of signaling pathways in which various components are subjected to activating genetic alterations in acute myeloid leukemia (AML), thus contributing to oncogenesis. Three AKT isoforms exist in humans. However, whether one isoform predominates in AML remains unknown. This study reveals that AKT3 behaves very distinctly than AKT1 or AKT2 in both normal myeloid differe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6567fad0-4370-59c3-8fc5-38c7c6423392
DOI
10.21203/rs.3.rs-3660527/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Prognostic impacts of the three AKT isoforms in acute myeloid leukemia. Is AKT3 the bad AKTOR?DOI 10.21203/rs.3.rs-3660527/v1
Differential prognostic values of the three AKT isoforms in acute myeloid leukemia.Semantic proximity
PI3K/AKT pathway activation in acute myeloid leukaemias is not associated with AKT1 pleckstrin homology domain mutation.Semantic proximity
Constitutive Activation of Akt by Flt3 Internal Tandem Duplications Is Necessary for Increased Survival, Proliferation, and Myeloid TransformationSemantic proximity
Constitutive phosphoinositide 3-kinase/Akt activation represents a favorable prognostic factor in de novo acute myelogenous leukemia patientsSemantic proximity
Outlook on PI3K/AKT/mTOR inhibition in acute leukemiaSemantic proximity
Signalling specificity in the Akt pathway in breast cancerSemantic proximity
AKT: A Central Node in Complex Signaling CascadesSemantic proximity
Emerging Roles for AKT Isoform Preference in Cancer Progression PathwaysSemantic proximity
AKT isoform-specific expression and activation across cancer lineages.Semantic proximity
Targeting the Akt, GSK-3, Bcl-2 axis in acute myeloid leukemiaSemantic proximity
Akt: a key transducer in cancerSemantic proximity
Two acute myeloid leukemia patient subsets are identified based on the constitutive PI3K-Akt-mTOR signaling of their leukemic cells; a functional, proteomic, and transcriptomic comparison.Semantic proximity
Select a neighboring publication to make it the new centre.