Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele.

Human molecular genetics - 15 Jan 2013

Chen Li, Faire Mehlika, Kissner Michael D, Laird Diana J

Abstract excerpt

KitL, via its receptor cKit, supports primordial germ cell (PGC) growth, survival, migration and reprogramming to pluripotent embryonic germ cells (EGCs). However, the signaling downstream of KitL and its regulation in PGCs remain unclear. A constitutively activating mutation, cKit(V558Δ), causes gain-of-function phenotypes in mast cells and intestines, and gastrointestinal stromal tumors (GISTs) when...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to Enzyme Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gastrointestinal Neoplasms

Share to Gastrointestinal Stromal Tumors

Share to Germ Cells

Share to Mitogen-Activated Protein Kinases

Share to Proto-Oncogene Proteins c-akt

Share to Proto-Oncogene Proteins c-kit

Source

Open in PubMed Open full text

Identifiers

PMID: 23077213
DOI: 10.1093/hmg/dds430
PMCID: PMC3526162

Genes

PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele.PMID 23077213Read ↗

A knock-in mouse model of gastrointestinal stromal tumor harboring kit K641E.Semantic proximity Read ↗

Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit.Semantic proximity Read ↗

Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor.Semantic proximity Read ↗

Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinaseSemantic proximity Read ↗

Analysis of hypomorphic KitlSl mutants suggests different requirements for KITL in proliferation and migration of mouse primordial germ cells.Semantic proximity Read ↗

Coactivation of STAT and Ras is required for germ cell proliferation and invasive migration in Drosophila.Semantic proximity Read ↗

In vivo immunological function of mast cells derived from embryonic stem cells: an approach for the rapid analysis of even embryonic lethal mutations in adult mice in vivo.Semantic proximity Read ↗

GCL pruning of PIP3 establishes the soma-germline boundarySemantic proximity Read ↗

TSC1/2 tumour suppressor complex maintains Drosophila germline stem cells by preventing differentiation.Semantic proximity Read ↗

Kit signaling via PI3K promotes ovarian follicle maturation but is dispensable for primordial follicle activation.Semantic proximity Read ↗

Characterization of various types of mast cells derived from model mice of familial gastrointestinal stromal tumors with KIT-Asp818Tyr mutation.Semantic proximity Read ↗

Modeling sporadic loss of heterozygosity in mice by using mosaic analysis with double markers (MADM).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.