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Article

Differential prognostic values of the three AKT isoforms in acute myeloid leukemia.

Scientific reports - 25 Mar 2024

Corre Eulalie, Soum Cécile, Pfeifer Romain, Bessière Chloé, Dailhau Sandra, Marbœuf Catherine, Meggetto Fabienne, Touriol Christian, Récher Christian, Bousquet Marina, Pyronnet Stéphane

Abstract excerpt

The PI3K-AKT-mTOR pathway lies at the confluence of signaling pathways in which various components are subjected to activating genetic alterations in acute myeloid leukemia (AML), thus contributing to oncogenesis. Three AKT isoforms exist in humans. However, whether one isoform predominates in AML remains unknown. This study reveals that AKT3 behaves very distinctly than AKT1 or AKT2 in both normal myeloid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38528080
DOI: 10.1038/s41598-024-57578-x
PMCID: PMC10963760

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