Article
Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation.
Cell research - 1 May 2013
Tao Ting, Shi Hui, Guan Yihong, Huang Delai, Chen Ye, Lane David P, Chen Jun, Peng Jinrong
Abstract excerpt
p53 protein turnover through the ubiquitination pathway is a vital mechanism in the regulation of its transcriptional activity; however, little is known about p53 turnover through proteasome-independent pathway(s). The digestive organ expansion factor (Def) protein is essential for the development of digestive organs. In zebrafish, loss of function of def selectively upregulates the expression of p53 response...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.