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Article

mir-11 limits the proapoptotic function of its host gene, dE2f1.

Genes & development - 1 Sept 2011

Truscott Mary, Islam Abul B M M K, López-Bigas Núria, Frolov Maxim V

Abstract excerpt

The E2F family of transcription factors regulates the expression of both genes associated with cell proliferation and genes that regulate cell death. The net outcome is dependent on cellular context and tissue environment. The mir-11 gene is located in the last intron of the Drosophila E2F1 homolog gene dE2f1, and its expression parallels that of dE2f1. Here, we investigated the role of miR-11 and found that...

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Identifiers

PMID: 21856777
DOI: 10.1101/gad.16947411
PMCID: PMC3175718

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