Article
Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions.
EMBO reports - 1 Oct 2012
Schulz Sarah, Chachami Georgia, Kozaczkiewicz Lukasz, Winter Ulrike, Stankovic-Valentin Nicolas, Haas Petra, Hofmann Kay, Urlaub Henning, Ovaa Huib, Wittbrodt Joachim, Meulmeester Erik, Melchior Frauke
Abstract excerpt
Isopeptidases are essential regulators of protein ubiquitination and sumoylation. However, only two families of SUMO isopeptidases are at present known. Here, we report an activity-based search with the suicide inhibitor haemagglutinin (HA)-SUMO-vinylmethylester that led to the identification of a surprising new SUMO protease, ubiquitin-specific protease-like 1 (USPL1). Indeed, USPL1 neither binds nor cleaves...
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