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Article

Regulation of protein quality control by UBE4B and LSD1 through p53-mediated transcription.

PLoS biology - 1 Apr 2015

Periz Goran, Lu Jiayin, Zhang Tao, Kankel Mark W, Jablonski Angela M, Kalb Robert, McCampbell Alexander, Wang Jiou

Abstract excerpt

Protein quality control is essential for clearing misfolded and aggregated proteins from the cell, and its failure is associated with many neurodegenerative disorders. Here, we identify two genes, ufd-2 and spr-5, that when inactivated, synergistically and robustly suppress neurotoxicity associated with misfolded proteins in Caenorhabditis elegans. Loss of human orthologs ubiquitination factor E4 B (UBE4B) and...

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Identifiers

PMID: 25837623
DOI: 10.1371/journal.pbio.1002114
PMCID: PMC4383508

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