Article
DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription.
PloS one - 1 Jan 2012
Sancho Ana, Duran Jordi, García-España Antonio, Mauvezin Caroline, Alemu Endalkachew A, Lamark Trond, Macias Maria J, DeSalle Rob, Royo Miriam, Sala David, Chicote Javier U, Palacín Manuel, Johansen Terje, Zorzano Antonio
Abstract excerpt
Human DOR/TP53INP2 displays a unique bifunctional role as a modulator of autophagy and gene transcription. However, the domains or regions of DOR that participate in those functions have not been identified. Here we have performed structure/function analyses of DOR guided by identification of conserved regions in the DOR gene family by phylogenetic reconstructions. We show that DOR is present in metazoan species....
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