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The unfolded protein response in metazoan development

15 Feb 2019

Abstract excerpt

ABSTRACT Eukaryotic cells respond to an overload of unfolded proteins in the endoplasmic reticulum (ER) by activating signaling pathways that are referred to as the unfolded protein response (UPR). Much UPR research has been conducted in cultured cells that exhibit no baseline UPR activity until they are challenged by ER stress initiated by chemicals or mutant proteins. At the same time, many genes that mediate...

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PMID: 30770479
DOI: 10.1242/jcs.217216

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