Article
Dynamics of stochastic mutation to immunodominance.
Mathematical biosciences and engineering : MBE - 1 Oct 2012
Wu Yu, Zhao Xiaopeng, Zhang Mingjun
Abstract excerpt
Although a virus contains several epitopes that can be recognized by cytotoxic T lymphocytes (CTL), the immune responses against different epitopes are not uniform. Only a few CTLs (sometimes just one) will be immunodominant. Mutation of epitopes has been recognized as an important mechanism of immunodominance. Previous research has studied the influences of sporadic, discrete mutation events. In this work, we...
Topics
- Animals
- Humans
- Immunodominant Epitopes
- Models, Genetic
- Models, Immunological
- Models, Statistical
- Mutation
- Stochastic Processes
- T-Lymphocytes, Cytotoxic
- Virus Physiological Phenomena