Evolution of antigen drift/switching: continuously evading pathogens.

doi:10.1006/jtbi.1994.1110

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Article

Evolution of antigen drift/switching: continuously evading pathogens.

Journal of theoretical biology - 7 Jun 1994

Sasaki A

Abstract excerpt

Following infection to a host, some pathogens repeatedly alter their antigen expression, and thereby escape the immune defense (antigen drift/switching). This paper examines the evolutionarily stable mutation rate of pathogens which maximizes the stationary pathogen density in a host. Assumptions...

Topics

Alleles
Animals
Antigenic Variation
Antigens, Bacterial
Antigens, Protozoan
Antigens, Surface
Antigens, Viral
Biological Evolution
Epitopes
Models, Biological
Mutation

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