Article
Fluctuating fitness shapes the clone-size distribution of immune repertoires.
Proceedings of the National Academy of Sciences of the United States of America - 12 Jan 2016
Desponds Jonathan, Mora Thierry, Walczak Aleksandra M
Abstract excerpt
The adaptive immune system relies on the diversity of receptors expressed on the surface of B- and T cells to protect the organism from a vast amount of pathogenic threats. The proliferation and degradation dynamics of different cell types (B cells, T cells, naive, memory) is governed by a variety of antigenic and environmental signals, yet the observed clone sizes follow a universal power-law distribution....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.