Article
Evolutionary pattern of intra-host pathogen antigenic drift: effect of cross-reactivity in immune response.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Jan 1997
Haraguchi Y, Sasaki A
Abstract excerpt
Several viruses are known to change their surface antigen types after infecting a host, thereby escaping the immune defence and ensuring persistent infection. In this paper, we theoretically study the pattern of intra-host micro-evolution of pathogen antigen variants under the antigen specific immune response. We assume that the antigen types of the pathogen can be indexed in one-dimensional space, and that a...
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