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Article

Quantifying how MHC polymorphism prevents pathogens from adapting to the antigen presentation pathway.

Epidemics - 1 Sept 2010

Schmid B V, Kęsmir C, de Boer R J

Abstract excerpt

The classical antigen presentation pathway consists of two monomorphic (proteasome and TAP) and one polymorphic components (MHC Class I). Viruses can escape CTL responses by mutating an epitope so that it is no longer correctly processed by the pathway. Whereas escape mutations that affect MHC binding are typically no longer under selection pressure in the next host of the virus (as hosts differ in their MHC...

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Source

Identifiers

PMID: 21352780
DOI: 10.1016/j.epidem.2010.05.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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