Article
A mathematical model of vaccination against HIV to prevent the development of AIDS.
Proceedings. Biological sciences - 22 Nov 1991
Nowak M A, McLean A R
Abstract excerpt
Vaccination and post-exposure immunization against the human immunodeficiency viruses (HIV-1 and HIV-2) faces the problem of the extensive genetic and antigenic variability of these viruses. This raises the question of what fraction of all possible antigen strains of the virus must be recognized by the immune response to a vaccine to prevent development of acquired immunodeficiency disease (AIDS). The success of...
Topics
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Antigenic Variation
- HIV Antigens
- Humans
- Models, Biological
- Mutation
- Stochastic Processes
- Time Factors
- Vaccination