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Article

Sequence Space Localization in the Immune System Response to Vaccination and Disease

7 Aug 2003

Abstract excerpt

We introduce a model of protein evolution to explain limitations in the immune system response to vaccination and disease. The phenomenon of original antigenic sin, wherein vaccination creates memory sequences that can increase susceptibility to future exposures to the same disease, is explained as stemming from localization of the immune system response in antibody sequence space. This localization is a result...

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PMID: 12935112
DOI: 10.1103/physrevlett.91.068101

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