Article
Modelling the role of immunity in reversion of viral antigenic sites
2015-09-30
Abstract excerpt
Antigenic sites in viral pathogens exhibit distinctive evolutionary dynamics due to their role in evading recognition by host immunity. Antigenic selection is known to drive higher rates of non-synonymous substitution; less well understood is why differences are observed between viruses in their propensity to mutate to a novel or previously encountered amino acid. Here, we present a model to explain patterns of an...
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Identifiers and source
- Literature Corpus work
- f5fdcbd2-0e88-52f9-8127-adc38ad3f892
- DOI
- 10.1101/027995