Article
Sortilin-related VPS10 domain containing receptor 1 and Alzheimer's disease-associated allelic variations preferentially exist in female or type 2 diabetes mellitus patients in southern Han Chinese.
Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society - 1 Dec 2012
He Yanqin, Fang Zhuyuan, Yu Guran
Abstract excerpt
BACKGROUND: Both in vitro and in vivo, overexpression of the sortilin-related VPS10 domain containing receptor 1 (SORCS1) protein lowers amyloid-β generation. Recent studies have shown that SORCS1 variations in intron 1 are associated with sporadic Alzheimer's disease (SAD), but the results remain inconsistent. METHODS: In order to clarify the role of the SORCS1 gene in southern Han Chinese, we genotyped eight...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.