SORCS1 and APOE polymorphisms interact to confer risk for late-onset Alzheimer's disease in a Northern Han Chinese population.

doi:10.1016/j.brainres.2012.01.067

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SORCS1 and APOE polymorphisms interact to confer risk for late-onset Alzheimer's disease in a Northern Han Chinese population.

Brain research - 11 Apr 2012

Wang Hui-Fu, Yu Jin-Tai, Zhang Wei, Wang Wei, Liu Qiu-Yan, Ma Xiao-Ying, Ding Hua-Min, Tan Lan

Abstract excerpt

Sortilin-related VPS domain containing receptor 1 (SORCS1), is located on chromosome 10q23.3, a chromosomal region of interest in Alzheimer's disease (AD) defined by many genome-wide and chromosome10-specific studies. Recently, three intronic variants (rs12571141, rs17277986 and rs6584777) within SORCS1 were reported to be associated with AD in Caucasian. In order to assess the involvement of the SORCS1...

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PMID: 22353753
DOI: 10.1016/j.brainres.2012.01.067

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SORCS1
APOE

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