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Article

Association of SORL1 polymorphisms and SORL1-APOE ε4 interaction with risk of subjective cognitive decline and mild cognitive impairment in the Chinese population.

Journal of Alzheimer's disease : JAD - 1 Jun 2026

Meng Fanfan, Zhao Tingting, Yang Xi, Li Hanbo, Wang Jiaping, Zhu Qingyun, Liu Jin, Wang Tong, Zhu Yi

Abstract excerpt

BackgroundAlzheimer's disease (AD) is a multifactorial disorder. The sortilin-related receptor 1 (SORL1) gene, which regulates the trafficking and recycling of amyloid precursor protein, has been reported to be associated with the development of AD.ObjectiveThis study investigated the impact of SORL1 polymorphisms (rs641120 and rs1784933) and their interaction with the apolipoprotein E (APOE) ε4 allele on AD...

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Source

Identifiers

PMID: 41995578
DOI: 10.1177/13872877261441644

Genes

SCD
SORL1
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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