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Article

Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP).

Translational psychiatry - 14 May 2013

Reitz C, Tosto G, Vardarajan B, Rogaeva E, Ghani M, Rogers R S, Conrad C, Haines J L, Pericak-Vance M A, Fallin M D, Foroud T, Farrer L A, Schellenberg G D, George-Hyslop P S, Mayeux R

Abstract excerpt

Genetic variants in the sortilin-related receptor (SORL1) and the sortilin-related vacuolar protein sorting 10 (VPS10) domain-containing receptor 1 (SORCS1) are associated with increased risk of Alzheimer's disease (AD), declining cognitive function and altered amyloid precursor protein (APP) processing. We explored whether other members of the (VPS10) domain-containing receptor protein family (the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23673467
DOI: 10.1038/tp.2013.13
PMCID: PMC3669917

Genes

SORCS2
SORCS3
APP
SORCS1
SORL1
SORT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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