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Article

A Genetic Variant of the Sortilin 1 Gene is Associated with Reduced Risk of Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jul 2016

Andersson Carl-Henrik, Hansson Oskar, Minthon Lennart, Andreasen Niels, Blennow Kaj, Zetterberg Henrik, Skoog Ingmar, Wallin Anders, Nilsson Staffan, Kettunen Petronella

Abstract excerpt

Alzheimer's disease (AD) is a neurodegenerative disorder represented by the accumulation of intracellular tau protein and extracellular deposits of amyloid-β (Aβ) in the brain. The gene sortilin 1 (SORT1) has previously been associated with cardiovascular disease in gene association studies. It has also been proposed to be involved in AD pathogenesis through facilitating Aβ clearance by binding apoE/Aβ complexes...

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Source

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Identifiers

PMID: 27392867
DOI: 10.3233/JAD-160319
PMCID: PMC5147507

Genes

SORT1
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A Genetic Variant of the Sortilin 1 Gene is Associated with Reduced Risk of Alzheimer's Disease.PMID 27392867Read ↗

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