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An updated meta-analysis of the association between SORL1 variants and the risk for sporadic Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2013

Jin Chunhui, Liu Xiaowei, Zhang Fuquan, Wu Yue, Yuan Jianmin, Zhu Jianzhong, Zhang Feng, Wang Guoqiang, Cheng Zaohuo

Abstract excerpt

The pathogenetic mechanism of Alzheimer's disease (AD) is still unknown; however, genetic variants play a critical role in the pathogenesis of AD. It has been reported that single nucleotide polymorphisms (SNPs) of the sortilin-related receptor with A-type repeats (SORL1, also called LR11 or sorLA) are associated with late-onset AD in Caucasian populations. Subsequently, other researchers have attempted to...

Topics

Alzheimer Disease
China
Databases, Bibliographic
Genetic Predisposition to Disease
Humans
LDL-Receptor Related Proteins
Linkage Disequilibrium
Membrane Transport Proteins
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23948893
DOI: 10.3233/JAD-130533

Genes

SORL1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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