Article
Genetic variants in caspase genes and susceptibility to non-Hodgkin lymphoma.
Carcinogenesis - 1 Apr 2007
Lan Qing, Zheng Tongzhang, Chanock Stephen, Zhang Yawei, Shen Min, Wang Sophia S, Berndt Sonja I, Zahm Shelia H, Holford Theodore R, Leaderer Brian, Yeager Meredith, Welch Robert, Hosgood Dean, Boyle Peter, Rothman Nathaniel
Abstract excerpt
The caspase proteins are essential for the regulation of normal B cell development and regulation of apoptosis. We investigated five single nucleotide polymorphisms in four key caspase genes, CASP3 [Ex8-280C>A (rs6948) and Ex8+567T>C (rs1049216)], CASP8 Ex14-271A>T (rs13113), CASP9 Ex5+32G>A (rs1052576) and CASP10 Ex3-171A>G (rs3900115) to determine whether they alter risk for non-Hodgkin lymphoma (NHL) in a...