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CASP8 polymorphisms contribute to cancer susceptibility: evidence from a meta-analysis of 23 publications with 55 individual studies.

Carcinogenesis - 1 May 2010

Yin Ming, Yan Jingrong, Wei Sheng, Wei Qingyi

Abstract excerpt

Several potentially functional polymorphisms of CASP8 encoding an apoptotic enzyme, caspase 8, have been implicated in cancer risk, but individually published studies showed inconclusive results. We performed a meta-analysis of 23 publications with a total of 55 174 cancer cases and 59 336 controls from 55 individual studies. We summarized the data on the associations between three studied CASP8 polymorphisms...

Topics

Caspase 8
Gene Deletion
Genetic Predisposition to Disease
Genotype
Humans
Neoplasms
Polymorphism, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 20176653
DOI: 10.1093/carcin/bgq047
PMCID: PMC2864415

Genes

CASP8

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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