Defective presentation of endogenous antigen by a cell line expressing class I molecules.

doi:10.1126/science.2326647

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Article

Defective presentation of endogenous antigen by a cell line expressing class I molecules.

Science (New York, N.Y.) - 20 Apr 1990

Hosken N A, Bevan M J

Abstract excerpt

Cytotoxic T lymphocytes (CTLs) recognize class I major histocompatibility complex (MHC) molecules associated with antigenic peptides derived from endogenously synthesized proteins. Binding to such peptides is a requirement for class I assembly in the endoplasmic reticulum (ER). A mutant human cel...

Topics

Animals
Antigen-Presenting Cells
Antigens
Antigens, Viral
B-Lymphocytes
Capsid
Cell Line
Endoplasmic Reticulum
Gene Expression
H-2 Antigens
HLA Antigens
Histocompatibility Antigens Class I
Histocompatibility Antigens Class II
Humans
Mice
Mutation
Ovalbumin
Peptides

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