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Article

Role of endogenous peptides in murine allogenic cytotoxic T cell responses assessed using transfectants of the antigen-processing mutant 174xCEM.T2.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 1992

Crumpacker D B, Alexander J, Cresswell P, Engelhard V H

Abstract excerpt

One model to explain the high frequency of alloreactive T cells proposes that allogeneic MHC molecules are recognized together with host cell-derived peptides. A model system was developed to investigate the relevance of this mechanism by expression of H-2Dd or H-2Ld in 174xCEM.T2 (T2) cells. This human cell line contains a mutation in its Ag-processing pathway that should restrict the association of endogenous...

Topics

Animals
Cell Line
Epitopes
H-2 Antigens
HLA-A2 Antigen
Humans
Isoantigens
Mice
Mutation
Peptides
T-Lymphocytes, Cytotoxic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transfection

Source

Identifiers

PMID: 1374446

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1374446-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Role of endogenous peptides in murine allogenic cytotoxic T cell responses assessed using transfectants of the antigen-processing mutant 174xCEM.T2.PMID 1374446Read ↗

Alloreactive T cells discriminate among a diverse set of endogenous peptides.Semantic proximity Read ↗

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