Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antigen processing mutant T2 cells present viral antigen restricted through H-2Kb.

European journal of immunology - 1 Aug 1993

Zhou X, Glas R, Liu T, Ljunggren H G, Jondal M

Abstract excerpt

Cytotoxic T lymphocytes (CTL) recognize foreign antigens as short peptides presented by class I molecules of the major histocompatibility complex (MHC). T2 cells are profoundly defective in the presentation of endogenously synthesized antigens to CTL due to a deletion of MHC class II-encoded genes for transporters associated with antigen presentation (TAP1/TAP2). Surprisingly, we here demonstrate that T2 cells,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigen-Presenting Cells
Share to Antigens, Viral
Share to Cell Line

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to H-2 Antigens

Share to Mice, Inbred C57BL

Share to Mutation

Share to T-Lymphocytes, Cytotoxic

Source

Identifiers

PMID: 8393799
DOI: 10.1002/eji.1830230811

Genes

TAP1
TAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antigen processing mutant T2 cells present viral antigen restricted through H-2Kb.PMID 8393799Read ↗

Defective presentation of endogenous antigen by a cell line expressing class I molecules.Semantic proximity Read ↗

LAMP-2-deficient human B cells exhibit altered MHC class II presentation of exogenous antigens.Semantic proximity Read ↗

Presentation of endogenous peptides to MHC class I-restricted cytotoxic T lymphocytes in transport deletion mutant T2 cells.Semantic proximity Read ↗

Expression of HLA class I antigens in transporter associated with antigen processing (TAP)-deficient mutant cell lines.Semantic proximity Read ↗

Stage-specific inhibition of MHC class I presentation by the Epstein-Barr virus BNLF2a protein during virus lytic cycle.Semantic proximity Read ↗

A point mutation in the human transporter associated with antigen processing (TAP2) alters the peptide transport specificity.Semantic proximity Read ↗

Genetics of antigen processing and presentationSemantic proximity Read ↗

Specific Targeting of the EBV Lytic Phase Protein BNLF2a to the Transporter Associated with Antigen Processing Results in Impairment of HLA Class I-Restricted Antigen PresentationSemantic proximity Read ↗

The antigen-processing mutant T2 suggests a role for MHC-linked genes in class II antigen presentation.Semantic proximity Read ↗

Presentation of cytosolic antigen by HLA-DR requires a function encoded in the class II region of the MHC.Semantic proximity Read ↗

Reduced expression of the transporter associated with antigen processing 1 molecule in malignant glioma cells, and its restoration by interferon-gamma and -beta.Semantic proximity Read ↗

LMP2+ proteasomes are required for the presentation of specific antigens to cytotoxic T lymphocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.