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Article

Impaired antigen presentation by murine I-Ad class II MHC molecules expressed in normal and HLA-DM-defective human B cell lines.

International immunology - 1 Jun 1997

Weenink S, Averdunk H, Boston T, Boswarva V, Guery J C, Adorini L, Mellins E, McCluskey J, Gautam A M

Abstract excerpt

The inability of certain antigen processing mutant cell lines to present intact proteins to T cells and to form SDS-stable MHC class II dimers has been shown to result from defective expression of HLA-encoded DMA and DMB genes. We have utilized some of these mutants to determine species compatibility of antigen presentation components. Mouse MHC class II I-Ad cDNA was transfected into the human B cell...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9199972
DOI: 10.1093/intimm/9.6.889

Genes

SDS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Impaired antigen presentation by murine I-Ad class II MHC molecules expressed in normal and HLA-DM-defective human B cell lines.PMID 9199972Read ↗

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The antigen-processing mutant T2 suggests a role for MHC-linked genes in class II antigen presentation.Semantic proximity Read ↗

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Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells.Semantic proximity Read ↗

Amino acid substitutions in the putative MHC class II "dimer of dimers" interface inhibit CD4+ T cell activation.Semantic proximity Read ↗

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Antigen presentation and T cell development in H2-M-deficient mice.Semantic proximity Read ↗

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