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Article

HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides.

Nature - 3 Dec 1992

Riberdy J M, Newcomb J R, Surman M J, Barbosa J A, Cresswell P

Abstract excerpt

The invariant chain, which associates with the major histocompatibility complex (MHC) class II molecules in the endoplasmic reticulum, serves two functions important in antigen processing. First, it prevents class II molecules from binding peptides in the early stages of intracellular transport. Second, it contains a cytoplasmic signal that targets the class II-invariant chain complex to an acidic endosomal...

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PMID: 1448172
DOI: 10.1038/360474a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides.PMID 1448172Read ↗

Transport and intracellular distribution of MHC class II molecules and associated invariant chain in normal and antigen-processing mutant cell lines.Semantic proximity Read ↗

Identification of residues in the class II-associated Ii peptide (CLIP) region of invariant chain that affect efficiency of MHC class II-mediated antigen presentation in an allele-dependent manner.Semantic proximity Read ↗

In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides.Semantic proximity Read ↗

HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides.Semantic proximity Read ↗

Promiscuous binding of invariant chain-derived CLIP peptide to distinct HLA-I molecules revealed in leukemic cells.Semantic proximity Read ↗

Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II.Semantic proximity Read ↗

The antigen-processing mutant T2 suggests a role for MHC-linked genes in class II antigen presentation.Semantic proximity Read ↗

Defective presentation of endogenous antigen by a cell line expressing class I molecules.Semantic proximity Read ↗

HLA-A2.1-associated peptides from a mutant cell line: a second pathway of antigen presentation.Semantic proximity Read ↗

Allele-dependent processing pathways generate the endogenous human leukocyte antigen (HLA) class I peptide repertoire in transporters associated with antigen processing (TAP)-deficient cells.Semantic proximity Read ↗

The CLIP-substituted invariant chain efficiently targets an antigenic peptide to HLA class II pathway in L cells.Semantic proximity Read ↗

Physical and functional association of the major histocompatibility complex class I heavy chain alpha3 domain with the transporter associated with antigen processing.Semantic proximity Read ↗

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