Article
HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides.
Nature - 3 Dec 1992
Riberdy J M, Newcomb J R, Surman M J, Barbosa J A, Cresswell P
Abstract excerpt
The invariant chain, which associates with the major histocompatibility complex (MHC) class II molecules in the endoplasmic reticulum, serves two functions important in antigen processing. First, it prevents class II molecules from binding peptides in the early stages of intracellular transport. Second, it contains a cytoplasmic signal that targets the class II-invariant chain complex to an acidic endosomal...
Topics
- Amino Acid Sequence
- Antibodies, Monoclonal
- Cell Line
- Chromatography, High Pressure Liquid
- Electrophoresis, Polyacrylamide Gel
- HLA-DR2 Antigen
- Homozygote
- Humans
- Macromolecular Substances
- Molecular Sequence Data