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Article

The antigen-processing mutant T2 suggests a role for MHC-linked genes in class II antigen presentation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 1992

Riberdy J M, Cresswell P

Abstract excerpt

.174xCEM.T2 (T2) is a human cell hybrid that has a large homozygous deletion within the MHC, including all of the functional class II genes. We have generated stable HLA-DR3 and H-2 I-Ak transfectants of T2 that express parental levels of class II molecules at the cell surface. T2.Ak transfectants fail to stimulate a hen egg lysozyme (HEL)-specific, I-Ak-restricted T cell when incubated with intact HEL. However,...

Topics

Epitopes
HLA-DR3 Antigen
Histocompatibility Antigens Class II
Humans
Hybrid Cells
Major Histocompatibility Complex
Mutation
Transfection

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 1373173

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SDS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1373173-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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