Article
HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides.
Nature - 2 Apr 1992
Wei M L, Cresswell P
Abstract excerpt
The mutant human cell line T2 is defective in antigen presentation in the context of class I major histocompatibility complex (MHC) molecules, and also in that transfected T2 cells show poor surface expression of exogenous human class I (HLA) alleles. Both defects are thought to lie in the transport of antigenic peptides derived from cytosolic proteins into the endoplasmic reticulum (ER), as peptide-deficient...
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