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Article

HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides.

Nature - 2 Apr 1992

Wei M L, Cresswell P

Abstract excerpt

The mutant human cell line T2 is defective in antigen presentation in the context of class I major histocompatibility complex (MHC) molecules, and also in that transfected T2 cells show poor surface expression of exogenous human class I (HLA) alleles. Both defects are thought to lie in the transport of antigenic peptides derived from cytosolic proteins into the endoplasmic reticulum (ER), as peptide-deficient...

Topics

Alleles
Amino Acid Sequence
Cell Line
Cell Membrane
Genes, MHC Class I
HLA Antigens
HLA-A Antigens
HLA-A2 Antigen
HLA-B Antigens
Humans
Major Histocompatibility Complex
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Transfection

Source

Identifiers

PMID: 1557127
DOI: 10.1038/356443a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1557127-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides.PMID 1557127Read ↗

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Intracellular transport of class I MHC molecules in antigen processing mutant cell lines.Semantic proximity Read ↗

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Naturally processed HLA class I bound peptides from c-myc-transfected cells reveal allele-specific motifs.Semantic proximity Read ↗

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