Article
Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes.
Nature - 4 Jan 1990
Mellins E, Smith L, Arp B, Cotner T, Celis E, Pious D
Abstract excerpt
Presentation of an exogenous protein antigen to helper (CD4+)T-lymphocytes by antigen presenting cells (APC) generally requires that the APCs degrade the native protein antigen into an immunogenic peptide, a process termed 'antigen processing', and that this peptide bind to a major histocompatibility complex (MHC) class II molecule. The complex of peptide and MHC molecule on the APC surface provides the...
Topics
- Antigen-Presenting Cells
- CD4-Positive T-Lymphocytes
- Chloroquine
- Genes
- HLA-D Antigens
- Hepatitis B Surface Antigens
- Humans
- In Vitro Techniques
- Lymphocyte Activation
- Mutation
- Protein Conformation