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Article

Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes.

Nature - 4 Jan 1990

Mellins E, Smith L, Arp B, Cotner T, Celis E, Pious D

Abstract excerpt

Presentation of an exogenous protein antigen to helper (CD4+)T-lymphocytes by antigen presenting cells (APC) generally requires that the APCs degrade the native protein antigen into an immunogenic peptide, a process termed 'antigen processing', and that this peptide bind to a major histocompatibility complex (MHC) class II molecule. The complex of peptide and MHC molecule on the APC surface provides the...

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Identifiers

PMID: 1967485
DOI: 10.1038/343071a0

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes.PMID 1967485Read ↗

Mutations affecting antigen processing impair class II-restricted allorecognition.Semantic proximity Read ↗

A mutant antigen-presenting cell defective in antigen presentation expresses class II MHC molecules with an altered conformation.Semantic proximity Read ↗

Genetics of antigen processing and presentationSemantic proximity Read ↗

Gene required for normal MHC class II expression and function is localized to approximately 45 kb of DNA in the class II region of the MHC.Semantic proximity Read ↗

Identification of residues in the class II-associated Ii peptide (CLIP) region of invariant chain that affect efficiency of MHC class II-mediated antigen presentation in an allele-dependent manner.Semantic proximity Read ↗

Antigen presentation and assembly by mouse I-Ak class II molecules in human APC containing deleted or mutated HLA DM genes.Semantic proximity Read ↗

Mutant MHC class I molecules define interactions between components of the peptide-loading complex.Semantic proximity Read ↗

Novel mutants define genes required for the expression of human histocompatibility leukocyte antigen DM: evidence for loci on human chromosome 6p.Semantic proximity Read ↗

Defective presentation of endogenous antigen by a cell line expressing class I molecules.Semantic proximity Read ↗

HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides.Semantic proximity Read ↗

HLA-A2.1-associated peptides from a mutant cell line: a second pathway of antigen presentation.Semantic proximity Read ↗

Elucidation of the genetic basis of the antigen presentation defects in the mutant cell line .220 reveals polymorphism and alternative splicing of the tapasin gene.Semantic proximity Read ↗

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