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Article

Photo-activatable Ub-PCNA probes reveal new structural features of the Saccharomyces cerevisiae Polη/PCNA complex.

Nucleic acids research - 20 Sept 2021

Shen Siqi, Davidson Gregory A, Yang Kun, Zhuang Zhihao

Abstract excerpt

The Y-family DNA polymerase η (Polη) is critical for the synthesis past damaged DNA nucleotides in yeast through translesion DNA synthesis (TLS). TLS is initiated by monoubiquitination of proliferating cell nuclear antigen (PCNA) and the subsequent recruitment of TLS polymerases. Although individual structures of the Polη catalytic core and PCNA have been solved, a high-resolution structure of the complex of...

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PMID: 34390346
DOI: 10.1093/nar/gkab646
PMCID: PMC8450101

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