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Complex roles for proliferating cell nuclear antigen in restricting human cytomegalovirus replication

25 Mar 2025

Abstract excerpt

DNA viruses at once elicit and commandeer host pathways, including DNA repair pathways, for virus replication. Despite encoding its own DNA polymerase and processivity factor, human cytomegalovirus (HCMV) recruits the cellular processivity factor, proliferating cell nuclear antigen (PCNA) and specialized host DNA polymerases involved in translesion synthesis (TLS) to replication compartments (RCs) where viral DNA...

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PMID: 40130902
DOI: 10.1128/mbio.00450-25

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