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Article

p27(Kip1) directly represses Sox2 during embryonic stem cell differentiation.

Cell stem cell - 7 Dec 2012

Li Han, Collado Manuel, Villasante Aranzazu, Matheu Ander, Lynch Cian J, Cañamero Marta, Rizzoti Karine, Carneiro Carmen, Martínez Gloria, Vidal Anxo, Lovell-Badge Robin, Serrano Manuel

Abstract excerpt

The mechanisms responsible for the transcriptional silencing of pluripotency genes in differentiated cells are poorly understood. We have observed that cells lacking the tumor suppressor p27 can be reprogrammed into induced pluripotent stem cells (iPSCs) in the absence of ectopic Sox2. Interestingly, cells and tissues from p27 null mice, including brain, lung, and retina, present an elevated basal expression of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Enhancer Elements, Genetic

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Identifiers

PMID: 23217425
DOI: 10.1016/j.stem.2012.09.014
PMCID: PMC3549496

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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