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PROP1 triggers epithelial-mesenchymal transition-like process in pituitary stem cells

28 Jun 2016

Abstract excerpt

Mutations in PROP1 are the most common cause of hypopituitarism in humans; therefore, unraveling its mechanism of action is highly relevant from a therapeutic perspective. Our current understanding of the role of PROP1 in the pituitary gland is limited to the repression and activation of the pituitary transcription factor genes Hesx1 and Pou1f1, respectively. To elucidate the comprehensive PROP1-dependent gene...

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PMID: 27351100
DOI: 10.7554/elife.14470

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