Hereditary retinoblastoma iPSC model reveals aberrant spliceosome function driving bone malignancies.

doi:10.1073/pnas.2117857119

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Hereditary retinoblastoma iPSC model reveals aberrant spliceosome function driving bone malignancies.

Proceedings of the National Academy of Sciences of the United States of America - 19 Apr 2022

Tu Jian, Huo Zijun, Yu Yao, Zhu Dandan, Xu An, Huang Mo-Fan, Hu Ruifeng, Wang Ruoyu, Gingold Julian A, Chen Yi-Hung, Tsai Kuang-Lei, Forcioli-Conti Nicolas R, Huang Sarah X L, Webb Thomas R, Su Jie, Bazer Danielle A, Jia Peilin, Yustein Jason T, Wang Lisa L, Hung Mien-Chie, Zhao Zhongming, Huff Chad D, Shen Jingnan, Zhao Ruiying, Lee Dung-Fang

Abstract excerpt

The RB1 gene is frequently mutated in human cancers but its role in tumorigenesis remains incompletely defined. Using an induced pluripotent stem cell (iPSC) model of hereditary retinoblastoma (RB), we report that the spliceosome is an up-regulated target responding to oncogenic stress in RB1-mutant cells. By investigating transcriptomes and genome occupancies in RB iPSC–derived osteoblasts (OBs), we discover...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinogenesis

Share to Genes, Retinoblastoma

Share to Osteosarcoma

Share to Retinal Neoplasms

Share to Retinoblastoma

Share to Retinoblastoma Binding Proteins

Share to Spliceosomes

Source

Open in PubMed Open full text

Identifiers

PMID: 35412907
DOI: 10.1073/pnas.2117857119
PMCID: PMC9169787

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hereditary retinoblastoma iPSC model reveals aberrant spliceosome function driving bone malignancies.PMID 35412907Read ↗

Aberrant Retinoblastoma (RB)-E2F Transcriptional Regulation Defines Molecular Phenotypes of OsteosarcomaSemantic proximity Read ↗

Defective splicing of the RB1 transcript is the dominant cause of retinoblastomas.Semantic proximity Read ↗

Human embryonic stem cell-derived organoid retinoblastoma reveals a cancerous origin.Semantic proximity Read ↗

SF3B1K700E rewires splicing of cell cycle regulators.Semantic proximity Read ↗

Twists in views on RB functions in cellular signaling, metabolism and stem cells.Semantic proximity Read ↗

Integrated Epigenetic and Transcriptomic Profiling Reveals Dynamic Regulatory Networks Driving Retinoblastoma PathogenesisSemantic proximity Read ↗

Osteosarcoma: prognosis plateau warrants retinoblastoma pathway targeted therapySemantic proximity Read ↗

Modeling Developmental and Tumorigenic Aspects of Trilateral Retinoblastoma via Human Embryonic Stem CellsSemantic proximity Read ↗

Elucidating dynamics and regulation of alternative splicing in osteogenic differentiationSemantic proximity Read ↗

pRB-Depleted Pluripotent Stem Cell Retinal Organoids Recapitulate Cell State Transitions of Retinoblastoma Development and Suggest an Important Role for pRB in Retinal Cell DifferentiationSemantic proximity Read ↗

Transcriptional activation by pRB and its coordination with SWI/SNF recruitment.Semantic proximity Read ↗

Generation of an induced pluripotent stem cell line (LVPEIi002-A) with heterozygous RB1 mutation using peri-orbital fat derived mesenchymal cells of a patient with inherited retinoblastoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.